N'Golo Kante was omitted as Frank Lampard named his first starting line-up since returning to Chelsea as caretaker manager, with the midfielder rested ahead of the Blues' Champions League trip to Real Madrid.
Lampard opted to make two changes to Chelsea's side for Saturday's Premier League trip to Wolves, introducing England internationals Raheem Sterling and Conor Gallagher.
With Chelsea reverting to a back four after Bruno Saltor used a 3-5-2 system in Tuesday's goalless draw with Liverpool, Ben Chilwell was dropped to the bench and Kante was absent entirely.
Kante made his first Premier League start since last August against Liverpool, having missed the majority of the campaign with a hamstring injury.
However, Lampard played down any concerns regarding Kante's condition before kick-off, telling Sky Sports: "There's no worries with N'Golo. We're fine with him and managing him through.
"He's been out for a long time so we have a way of managing him. I was aware of that when I was at the club before.
"Then there are a couple of other selection issues, some small concerns, so we have to protect a couple of the players in the squad."
Mason Mount was also absent for the Blues, with reports suggesting the midfielder suffered a recurrence of a previous injury in training on Friday.
The Athletic reported Mount – who has been linked with a move away after failing to agree a new contract with the Blues – could also miss the first leg of Chelsea's quarter-final tie with Madrid.
Chelsea travel to the Santiago Bernabeu to face Carlo Ancelotti's European champions on Wednesday, before welcoming Los Blancos to Stamford Bridge six days later.
